This study aimed to test the hypothesis that a new myostatin inhibitor, a recombinant myostatin propeptide, can enhance the repair and regeneration of both muscle and bone in cases of deep penetrant injury. The study used a fibula osteotomy model with associated damage to lateral compartment muscles in mice. The results showed that blocking active myostatin with systemic injections of a recombinant myostatin propeptide improved muscle and bone repair.